Research from University College London and the London School of Hygiene and Tropical Medicine finds that an HbA1C level of 6.0-6.5%, generally known as “prediabetes”, is associated with a bad brain outcome. (I really shouldn’t eat this coffee cake as I write this). Those with a hemoglobin A1C level in that range are 42% more likely to experience cognitive decline over the following four years. Further, 54% more likely to develop vascular dementia over the next eight. Vascular dementia is a result of insufficient blood flow to the brain.
As references: current literature has normal HbA1C as 5.7% and ideal >5.5%.
Standard treatment is as you expect: eat less, eat the right stuff, exercise more. If that doesn’t work, there are a number of prescription medicines to help.
Research was based on the UK Biobank which has health care tracking on ~ 500,000 individuals from 40-69. The data on about 450K folks was used.
Source: Diabetes, Obesity and Metabolism A Journal of Pharmacology and Therapeutics, 19 Jan 21.
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